Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5773943 | 0.83 | MAPK14 (0.42) | TLR9TLR8TLR7HTR6MAPK14 | |
| SCHEMBL5774851 | 0.82 | MAPK14 (0.48) | MAPK14MAPK13MAPK9CSNK1DGSK3B | |
| SCHEMBL5775115 | 0.82 | USP7 (0.41) | TLR9TLR8TLR7MAPK14MAPK13 | |
| SCHEMBL8125046 | 0.81 | MEN1 (0.44) | TLR9TLR7CDK2AURKBADORA1 | |
| SCHEMBL5774467 | 0.80 | TLR9 (0.37) | TLR9TLR8TLR7MAPK14MAPK13 | |
| Hydrochloric Acid SCHEMBL5775248 | 0.80 | KDM4E (0.44) | GABRA1GABRB2 | |
| SCHEMBL5774480 | 0.71 | KDM4E (0.44) | TLR9TLR8TLR7MAPK14MAPK13 | |
| SCHEMBL5776541 | 0.70 | MAPK14 (0.45) | TLR9TLR8TLR7MAPK14MAPK13 | |
| Hydrochloric Acid SCHEMBL5773701 | 0.70 | KDM4E (0.47) | GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL5807137 | 0.70 | KDM4E (0.43) | TLR9TLR8TLR7MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |