Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.41 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5776951 | 0.99 | KDM4E (0.43) | KDM4EHPGDSMN1; SMN2PLATGABRA1 | |
| Hydrochloric Acid SCHEMBL5775248 | 0.85 | KDM4E (0.44) | KDM4EHPGDSMN1; SMN2PLATGABRA1 | |
| Hydrochloric Acid SCHEMBL5807137 | 0.84 | KDM4E (0.43) | KDM4EHPGDSMN1; SMN2PLATGABRA1 | |
| Hydrochloric Acid SCHEMBL5773701 | 0.84 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2PLATGABRA1 | |
| SCHEMBL5775115 | 0.76 | USP7 (0.41) | KDM4EHPGDSMN1; SMN2GABRA1GABRB2 | |
| SCHEMBL5774851 | 0.76 | MAPK14 (0.48) | PLATGABRA1GABRB2HTR2CHTR2A | |
| SCHEMBL5776632 | 0.75 | GABRA1 (0.42) | GABRA1GABRB2SLC18A3SIGMAR1 | |
| SCHEMBL5777830 | 0.74 | SLC6A2 (0.43) | KDM4EHPGDSMN1; SMN2GABRA1HTR2C | |
| SCHEMBL8125046 | 0.74 | MEN1 (0.44) | PLATGABRA1GABRB2HTR2CHTR2A | |
| SCHEMBL5774467 | 0.71 | TLR9 (0.37) | KCNH2MAPK14MAPK13RAF1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |