Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774851 | 0.84 | MAPK14 (0.48) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| Hydrochloric Acid SCHEMBL5773701 | 0.76 | KDM4E (0.47) | PLATKCNH2HTR2AHTR2C | |
| SCHEMBL5774467 | 0.75 | TLR9 (0.37) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| Hydrochloric Acid SCHEMBL5807137 | 0.74 | KDM4E (0.43) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| Hydrochloric Acid SCHEMBL5773943 | 0.74 | MAPK14 (0.42) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| SCHEMBL5775115 | 0.72 | USP7 (0.41) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| SCHEMBL5776632 | 0.71 | GABRA1 (0.42) | — | |
| SCHEMBL5777830 | 0.71 | SLC6A2 (0.43) | HTR2C | |
| SCHEMBL8125046 | 0.71 | MEN1 (0.44) | PLATHTR2AHTR2CHTR2BTLR9 | |
| Hydrochloric Acid SCHEMBL5775248 | 0.70 | KDM4E (0.44) | PLATKCNH2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |