Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 11/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 11/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535706 | 0.79 | TRPA1 (0.50) | TP53TRPA1KDM1AALDH1A1MAPT | |
| SCHEMBL26984276 | 0.79 | TRPA1 (0.50) | TP53TRPA1KDM1AALDH1A1MAPT | |
| SCHEMBL2705811 | 0.79 | TRPA1 (0.50) | TP53TRPA1KDM1AALDH1A1MAPT | |
| SCHEMBL2706482 | 0.79 | TRPA1 (0.50) | TP53TRPA1KDM1AALDH1A1MAPT | |
| SCHEMBL7961187 | 0.79 | HTT (0.37) | HTTSLC9A1MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL27077286 | 0.78 | TRPA1 (0.49) | TP53TRPA1KDM1AALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL6119912 | 0.75 | KDM1A (0.41) | TP53TRPA1KDM1AALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL6119973 | 0.75 | KDM1A (0.41) | TP53TRPA1KDM1AALDH1A1MAPT | |
| SCHEMBL24366443 | 0.74 | GID4 (0.40) | MEN1KMT2AKDM1ARCOR1ALDH1A1 | |
| SCHEMBL8221834 | 0.71 | KDM1A (0.43) | HTTSLC9A1MEN1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323222-B1 | COGNITION ACTIVATORS, ALZHEIMER*S DISEASE AND ENZYME INHIBITORS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |