Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13141457 | 0.85 | BCHE (0.55) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| Irampanel SCHEMBL678128 | 0.84 | HTR7 (0.63) | SMN1; SMN2MAPTALDH1A1HTTTTR | |
| Irampanel SCHEMBL6879876 | 0.83 | HTR7 (0.62) | SMN1; SMN2MAPTALDH1A1HTTTTR | |
| SCHEMBL5959899 | 0.81 | TTR (0.72) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL7958621 | 0.80 | GPR55 (0.48) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL7947777 | 0.79 | TP53 (0.47) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL7947855 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTALDH1A1HTTTTR | |
| SCHEMBL7957207 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL7954980 | 0.78 | RAB9A (0.58) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL7958685 | 0.78 | NR1H4 (0.62) | SMN1; SMN2MAPTALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |