Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.81 |
| ▸ | RAB9A | P51151 | 11/20 | 0.81 |
| ▸ | NPC1 | O15118 | 10/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | TP53 | P04637 | 10/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.74 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.74 |
| ▸ | RELA | Q04206 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729285 | 0.89 | SMN1; SMN2 (0.77) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL3428143 | 0.89 | SMN1; SMN2 (0.77) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL14147338 | 0.88 | SMN1; SMN2 (0.75) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL12171135 | 0.87 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL6428833 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL16716023 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL61029 | 0.84 | NPC1 (0.70) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL13408282 | 0.81 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL23288082 | 0.81 | CASP3 (0.71) | SMN1; SMN2RAB9ANPC1GAATP53 | |
| SCHEMBL12692348 | 0.81 | RAB9A (0.67) | SMN1; SMN2RAB9ANPC1GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |