Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634035 | 0.93 | MAPT (0.44) | MAPTMEN1KMT2AATMPOLB | |
| SCHEMBL7958334 | 0.93 | MAPT (0.44) | MAPTMEN1KMT2AATMPOLB | |
| SCHEMBL7958424 | 0.93 | MAPT (0.44) | MAPTMEN1KMT2AATMPOLB | |
| SCHEMBL17654114 | 0.84 | MAPT (0.66) | MAPTMEN1KMT2AATMPOLB | |
| SCHEMBL17654181 | 0.84 | MAPT (0.54) | MAPTMEN1KMT2AATMPOLB | |
| SCHEMBL9760792 | 0.83 | POLB (0.51) | MAPTMEN1KMT2APOLBCYP2C9 | |
| SCHEMBL30114540 | 0.82 | HSPB1 (0.51) | MAPTMEN1KMT2APOLBCYP2C9 | |
| SCHEMBL12094284 | 0.81 | MAPT (0.48) | MAPTMEN1KMT2AATMPOLB | |
| SCHEMBL2814281 | 0.81 | MAPT (0.48) | MAPTMEN1KMT2APOLBCYP2C9 | |
| SCHEMBL3384471 | 0.80 | HRH3 (0.48) | MAPTMEN1KMT2ACYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |