Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956874 | 0.92 | ACACB (0.49) | POLBMAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3704174 | 0.84 | MAPT (0.65) | POLBMAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL7961706 | 0.83 | MAPT (0.46) | POLBMAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9761106 | 0.81 | SIGMAR1 (0.64) | POLBMAPTF10HRH3MEN1 | |
| SCHEMBL5864941 | 0.81 | SCD (0.56) | POLBMAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5632543 | 0.80 | CHKA (0.46) | POLBMAPTALDH1A1F10HRH3 | |
| SCHEMBL3439980 | 0.80 | POLB (0.73) | POLBMAPTALDH1A1SIRT6ADRB1 | |
| SCHEMBL9827139 | 0.80 | POLB (0.54) | POLBMAPTCYP2C9CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7954922 | 0.79 | CHKA (0.44) | POLBMAPTALDH1A1F10HRH3 | |
| SCHEMBL11044966 | 0.78 | EPHX2 (0.54) | POLBMAPTALDH1A1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |