Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958334 | 1.00 | MAPT (0.44) | MAPTMEN1KMT2AATMALDH1A1 | |
| SCHEMBL5634035 | 1.00 | MAPT (0.44) | MAPTMEN1KMT2AATMALDH1A1 | |
| SCHEMBL7961706 | 0.93 | MAPT (0.46) | MAPTMEN1KMT2AATMALDH1A1 | |
| SCHEMBL7956459 | 0.86 | MAPT (0.43) | MAPTPOLBACACBSCDMAPK1 | |
| SCHEMBL7956874 | 0.83 | ACACB (0.49) | MAPTALDH1A1CYP2C9POLBACACB | |
| SCHEMBL5632542 | 0.80 | ACACB (0.43) | ACACBLIPGHRH3 | |
| SCHEMBL7957015 | 0.80 | ACACB (0.41) | ACACBLIPGHRH3 | |
| SCHEMBL7954744 | 0.80 | FPR2 (0.43) | ACACBF10LIPGHRH3 | |
| SCHEMBL7961553 | 0.80 | ACACB (0.41) | ACACBLIPGHRH3 | |
| SCHEMBL7947301 | 0.80 | ACACB (0.41) | ACACBLIPGHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |