Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 5/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962392 | 0.90 | CYP11B2 (0.37) | KCNMA1CYP11B2PDE4BPDE4DABL1 | |
| SCHEMBL7953127 | 0.90 | KCNMA1 (0.36) | KCNMA1CYP11B2PDE4BPDE4DABL1 | |
| SCHEMBL7962136 | 0.88 | KCNMA1 (0.35) | KCNMA1CYP11B2ABL1KDM4E | |
| SCHEMBL7965300 | 0.87 | KCNMA1 (0.34) | KCNMA1CYP11B2PDE4BPDE4DABL1 | |
| SCHEMBL8327934 | 0.87 | DHODH (0.35) | KCNMA1CYP11B2PDE4BPDE4DABL1 | |
| SCHEMBL7961440 | 0.87 | KDM4E (0.35) | KCNMA1CYP11B2PDE4BPDE4DABL1 | |
| SCHEMBL7963132 | 0.87 | PDE4B (0.34) | KCNMA1CYP11B2PDE4BPDE4DABL1 | |
| SCHEMBL7961452 | 0.86 | KCNMA1 (0.38) | KCNMA1PDE4AKDM4ERECQL | |
| SCHEMBL7962855 | 0.84 | HCRTR1 (0.37) | KCNMA1PDE4BPDE4DABL1 | |
| SCHEMBL8331687 | 0.79 | CYP11B2 (0.41) | KCNMA1CYP11B2PDE4BPDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |