Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 9/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963132 | 0.90 | PDE4B (0.34) | HCRTR1HCRTR2KCNMA1ABL1PDE4B | |
| SCHEMBL7963885 | 0.89 | KCNMA1 (0.36) | HCRTR1HCRTR2KCNMA1KMT2AMEN1 | |
| SCHEMBL8327934 | 0.89 | DHODH (0.35) | KCNMA1ABL1KMT2APDE4BPDE4D | |
| SCHEMBL7961440 | 0.88 | KDM4E (0.35) | KCNMA1ABL1PDE4BPDE4D | |
| SCHEMBL7967665 | 0.87 | ABL1 (0.35) | HCRTR1HCRTR2ABL1KMT2AMEN1 | |
| SCHEMBL7964731 | 0.86 | FPR1 (0.35) | ABL1KMT2AMEN1ALDH1A1PDE4B | |
| SCHEMBL7962621 | 0.86 | ABL1 (0.35) | HCRTR1HCRTR2ABL1KMT2AMEN1 | |
| SCHEMBL7965416 | 0.84 | ABL1 (0.37) | HCRTR1ABL1KMT2AMEN1CDC7 | |
| SCHEMBL7961767 | 0.84 | KCNMA1 (0.38) | KCNMA1ABL1PDE4BPDE4D | |
| SCHEMBL7965300 | 0.83 | KCNMA1 (0.34) | HCRTR1HCRTR2KCNMA1ABL1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |