Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | KLK3 | P07288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963731 | 0.91 | CYP11B2 (0.39) | CYP11B2CYP11B1CYP17A1CYP19A1P2RX7 | |
| SCHEMBL8330546 | 0.91 | CYP11B2 (0.37) | MKNK1MKNK2CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL7962927 | 0.90 | NR4A2 (0.40) | CYP11B2CYP11B1CYP17A1CYP19A1P2RX7 | |
| SCHEMBL7953077 | 0.86 | MKNK1 (0.40) | MKNK1MKNK2CYP11B2P2RX7CSNK1D | |
| SCHEMBL7967737 | 0.84 | MKNK1 (0.39) | MKNK1MKNK2CYP11B2P2RX7CSNK1D | |
| SCHEMBL7967794 | 0.84 | MKNK1 (0.37) | MKNK1MKNK2CYP11B2CYP11B1P2RX7 | |
| Hydrochloric Acid SCHEMBL7964870 | 0.83 | MKNK1 (0.38) | MKNK1MKNK2CYP11B2P2RX7CSNK1D | |
| SCHEMBL7965202 | 0.82 | HPGD (0.32) | — | |
| SCHEMBL7964663 | 0.80 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP17A1CYP19A1PDE7A | |
| SCHEMBL7952322 | 0.80 | SQOR (0.34) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |