Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963731 | 0.91 | CYP11B2 (0.39) | NR4A2CYP11B2CYP19A1CYP11B1HTR2C | |
| SCHEMBL8330546 | 0.91 | CYP11B2 (0.37) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7961775 | 0.90 | MKNK1 (0.39) | NR4A2CYP11B2CYP19A1CYP11B1HTR2C | |
| SCHEMBL7954753 | 0.90 | NR4A2 (0.41) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7952692 | 0.82 | IDO1 (0.36) | MEN1KMT2AALDH1A1MAPK1HSP90AA1 | |
| SCHEMBL7963232 | 0.81 | NR4A2 (0.39) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7964663 | 0.80 | CYP11B2 (0.41) | CYP11B2CYP19A1CYP11B1MEN1KMT2A | |
| SCHEMBL7961829 | 0.80 | IDO1 (0.35) | MEN1KMT2AALDH1A1MAPK1HSP90AA1 | |
| SCHEMBL7955055 | 0.78 | KMT2A (0.55) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7954992 | 0.78 | CYP11B2 (0.41) | CYP11B2CYP11B1MAPK1CYP17A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |