Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 4/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963272 | 0.91 | GSK3B (0.32) | GSK3BFPR1FPR2 | |
| SCHEMBL8328950 | 0.91 | DHODH (0.37) | IDO1GSK3BFPR1FPR2 | |
| SCHEMBL7952322 | 0.90 | SQOR (0.34) | GSK3BFPR1FPR2 | |
| SCHEMBL7961118 | 0.90 | HSP90AA1 (0.35) | IDO1HSP90AA1GSK3BCDC7DBF4 | |
| SCHEMBL7952692 | 0.90 | IDO1 (0.36) | IDO1HSP90AA1GSK3BCDC7DBF4 | |
| SCHEMBL7967474 | 0.82 | HSP90AA1 (0.35) | IDO1HSP90AA1GSK3BCDC7DBF4 | |
| SCHEMBL7965124 | 0.81 | DHODH (0.32) | MAPT | |
| SCHEMBL8325837 | 0.81 | DHODH (0.38) | IDO1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7965202 | 0.80 | HPGD (0.32) | HPGD | |
| SCHEMBL7962634 | 0.80 | CYP11B2 (0.36) | ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |