Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 19/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 19/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 18/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972248 | 0.83 | GABRG2 (0.82) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7962331 | 0.79 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7973855 | 0.79 | GABRG2 (0.77) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7973849 | 0.78 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7978467 | 0.76 | MEN1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL341937 | 0.75 | GABRG2 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL342590 | 0.73 | GABRG2 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL341430 | 0.73 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL220805 | 0.72 | GABRG2 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6033234 | 0.72 | GABRG2 (0.75) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291460-B1 | TREATMENT OF ANXIETY; TREATMENT AND/OR PREVENTION OF CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-09-18 | — | — | US | claimed |
| US-6291460-B1 | TREATMENT OF ANXIETY; TREATMENT AND/OR PREVENTION OF CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-1056748-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037647-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |