Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 11/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973993 | 0.84 | GABRG2 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL341430 | 0.80 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7962330 | 0.78 | GABRA1 (0.56) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7984270 | 0.77 | BCHE (0.39) | ALDH1A1RXFP1LMNATDP1MEN1 | |
| SCHEMBL7962331 | 0.77 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7987417 | 0.74 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7984476 | 0.74 | GABRG2 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7972319 | 0.73 | GABRG2 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL342053 | 0.69 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7962537 | 0.69 | GABRG2 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | claimed |
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | disclosed |
| EP-1056747-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037649-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |