Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 3/20 | 0.55 |
| ▸ | F10 | P00742 | 3/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.55 |
| ▸ | F7 | P08709 | 3/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | F3 | P13726 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962444 | 1.00 | HPGD (0.56) | HPGDNPC1RAB9ASMN1; SMN2F2 | |
| SCHEMBL6373010 | 1.00 | HPGD (0.56) | HPGDNPC1RAB9ASMN1; SMN2F2 | |
| SCHEMBL6366936 | 0.88 | HPGD (0.55) | HPGDNPC1RAB9ASMN1; SMN2F2 | |
| SCHEMBL6366870 | 0.85 | PPARG (0.57) | SMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL6369033 | 0.85 | PPARG (0.57) | SMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL3959294 | 0.85 | PPARG (0.57) | SMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL9808697 | 0.84 | HPGD (0.59) | HPGDNPC1RAB9ASMN1; SMN2F2 | |
| SCHEMBL27476068 | 0.84 | NPC1 (0.58) | HPGDNPC1RAB9ASMN1; SMN2F2 | |
| SCHEMBL9416618 | 0.82 | MMP1 (0.55) | SMN1; SMN2F2F10PRSS1F7 | |
| SCHEMBL7134086 | 0.81 | CA1 (0.54) | HPGDNPC1RAB9ASMN1; SMN2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255301-B1 | CARDIOVASCULAR DISORDERS; ANTICOAGULANT; PROTEASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-07-03 | — | — | US | disclosed |