Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 13/20 | 0.70 |
| ▸ | TPSD1 | Q9BZJ3 | 13/20 | 0.70 |
| ▸ | TPSG1 | Q9NRR2 | 13/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413129 | 0.96 | TPSAB1 (0.68) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7420561 | 0.77 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7483058 | 0.77 | TPSAB1 (0.64) | TPSAB1TPSD1TPSG1PLGCYP2D6 | |
| SCHEMBL7960583 | 0.73 | TPSAB1 (0.64) | TPSAB1TPSD1TPSG1PLGCYP2D6 | |
| SCHEMBL10576741 | 0.73 | GAA (0.64) | TPSAB1TPSD1TPSG1KDM4EPKM | |
| SCHEMBL6261066 | 0.73 | GAA (0.46) | TPSAB1TPSD1TPSG1PRSS1KDM4E | |
| SCHEMBL14827431 | 0.71 | BRD4 (0.51) | TPSAB1TPSD1TPSG1PLGBRD4 | |
| SCHEMBL6390968 | 0.70 | GAA (0.53) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL29233709 | 0.70 | ALDH1A1 (0.43) | TPSAB1TPSD1TPSG1PRSS1GAA | |
| SCHEMBL8396874 | 0.70 | TPSAB1 (0.55) | TPSAB1TPSD1TPSG1EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |