Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30102496 | 0.90 | NPC1 (0.50) | CREBBPHDAC8HDAC1HDAC6L3MBTL1 | |
| SCHEMBL7164453 | 0.88 | HDAC1 (0.55) | CREBBPHDAC8HDAC1HDAC6L3MBTL1 | |
| SCHEMBL641868 | 0.85 | CREBBP (0.64) | CREBBPHDAC8HDAC1HDAC6HTT | |
| SCHEMBL7160525 | 0.83 | CREBBP (0.61) | CREBBPHDAC8HDAC1HDAC6HTT | |
| SCHEMBL4730758 | 0.83 | CREBBP (0.60) | CREBBPHDAC8HDAC1HDAC6L3MBTL1 | |
| SCHEMBL29463757 | 0.81 | CREBBP (0.72) | CREBBPHDAC8HDAC1HDAC6L3MBTL1 | |
| SCHEMBL3034164 | 0.81 | CREBBP (0.72) | CREBBPHDAC8HDAC1HDAC6L3MBTL1 | |
| SCHEMBL7922567 | 0.81 | SMN1; SMN2 (0.42) | CREBBPHDAC8HDAC1HDAC6TSHR | |
| SCHEMBL3385153 | 0.80 | TSHR (0.50) | HDAC8HDAC1HDAC6TSHRNPC1 | |
| SCHEMBL8204769 | 0.80 | CREBBP (0.66) | CREBBPHDAC8HDAC1HDAC6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0526004-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1997-10-08 | — | — | EP | disclosed |
| CN-1034503-C | Pyrazolopyrimidinone antianginal agents | PFIZER (US) | 1997-04-09 | — | — | CN | disclosed |
| US-5426107-A | Treatment of cardiovascular disorders, asthma, allergies | PFIZER INC. (US) | 1995-06-20 | — | — | US | disclosed |
| US-5272147-A | Pyrazolopyrimidinone antianginal agents | PFIZER INC. (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0526004-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1993-02-03 | — | — | EP | disclosed |
| CN-1068329-A | Pyrazolopyrimidinoneantianginal antianginal agents | PFIZER (US) | 1993-01-27 | — | — | CN | disclosed |