Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922226 | 0.87 | LMNA (0.50) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL7927917 | 0.86 | ALDH1A1 (0.50) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL30102496 | 0.84 | NPC1 (0.50) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL7962680 | 0.81 | CREBBP (0.62) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL10401303 | 0.78 | TSHR (0.44) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL1546638 | 0.77 | CYP2C19 (0.49) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL12942077 | 0.74 | GABRG2 (0.42) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL15423768 | 0.74 | KCNMA1 (0.48) | SMN1; SMN2NPC1USP2RAB9AHSD17B10 | |
| SCHEMBL3385153 | 0.74 | TSHR (0.50) | SMN1; SMN2NPC1USP2RAB9ATSHR | |
| SCHEMBL4729840 | 0.74 | KDM4E (0.57) | HSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085893-A1 | PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064033-A9 | PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES | ADVANCED MEDICINE INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999064033-A1 | PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |