SCHEMBL7962792

SCHEMBL7962792

[CH2]CCOC(C)(c1ccccc1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.45
HTR1A P08908 2/20 0.45
ADRA2A P08913 2/20 0.45
CHRM1 P11229 2/20 0.45
DRD1 P21728 2/20 0.45
SLC6A2 P23975 2/20 0.45
SLC6A4 P31645 2/20 0.45
ADRA1A P35348 2/20 0.45
OPRM1 P35372 2/20 0.45
DRD3 P35462 2/20 0.45
SLC6A3 Q01959 2/20 0.45
KCNH2 Q12809 2/20 0.45
HRH3 Q9Y5N1 2/20 0.45
TBXA2R P21731 1/20 0.45
ACHE P22303 1/20 0.45
MAPK1 P28482 1/20 0.41
CYP3A4 P08684 3/20 0.41
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 2/20 0.41
SLC22A1 O15245 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5594578 0.89 CHRM2 (0.59) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL10786977 0.83 CHRM2 (0.47) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL29090083 0.83 MAPK1 (0.44) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL25018337 0.81 CHRM2 (0.46) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL662478 0.79 KIF11 (0.64) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL663137 0.79 CHRM2 (0.45) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL28715515 0.79 CNR1 (0.44) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL27989498 0.78 KIF11 (0.63) CHRM2MAPK1CYP2C19CYP2C9TSHR
Moxastine SCHEMBL29281 0.76 CHRM2 (0.71) CHRM2HTR1AADRA2ACHRM1DRD1
SCHEMBL661183 0.76 MAPK1 (0.46) CHRM2HTR1AADRA2ACHRM1DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed