Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052500 | 0.94 | CARM1 (0.49) | CARM1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL22675642 | 0.80 | CARM1 (0.56) | CARM1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL4229926 | 0.80 | HTR7 (0.64) | SLC6A4DRD2DRD3HTR7HDAC3 | |
| SCHEMBL7962844 | 0.79 | ACACB (0.45) | SLC6A4DRD2DRD3HTR7ABCB1 | |
| SCHEMBL7976739 | 0.79 | DRD3 (0.74) | SLC6A4DRD2DRD3PRMT5HTR7 | |
| SCHEMBL22541512 | 0.79 | DRD3 (0.48) | DRD2DRD3HTR7ABCB1 | |
| Hydrochloric Acid SCHEMBL4222983 | 0.78 | HTR7 (0.62) | SLC6A4DRD2DRD3HTR7L3MBTL1 | |
| SCHEMBL4225899 | 0.78 | HTR7 (0.62) | SLC6A4DRD2DRD3HTR7HDAC3 | |
| Hydrochloric Acid SCHEMBL4224319 | 0.78 | HTR7 (0.62) | SLC6A4DRD2DRD3HTR7L3MBTL1 | |
| SCHEMBL27921604 | 0.78 | HTR7 (0.62) | SLC6A4DRD2DRD3HTR7HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274593-B1 | TREATING PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA, AND PARKINSON*S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-14 | — | — | US | disclosed |
| EP-0980357-A1 | SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998050363-A1 | SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |