Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962844 | 0.95 | ACACB (0.45) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL4382326 | 0.85 | ACACB (0.46) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL6979867 | 0.81 | PRMT5 (0.46) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL4390014 | 0.80 | ACACB (0.51) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL8052500 | 0.79 | CARM1 (0.49) | DRD3DRD2HTR7HTR1ASLC6A4 | |
| SCHEMBL6369620 | 0.79 | HRH3 (0.47) | DRD3DRD2ACACB | |
| SCHEMBL6984464 | 0.78 | DRD3 (0.52) | DRD3DRD2 | |
| SCHEMBL6977341 | 0.78 | DRD2 (0.61) | DRD3DRD2 | |
| SCHEMBL4229926 | 0.76 | HTR7 (0.64) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL7844061 | 0.76 | DRD2 (0.74) | DRD3DRD2HTR7HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0917530-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-02-19 | — | — | EP | disclosed |
| US-6046210-A | ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-04-04 | — | — | US | disclosed |
| EP-0917530-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-26 | — | — | EP | disclosed |
| WO-1997043262-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-11-20 | — | — | WO | disclosed |