Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CCND1 | P24385 | 3/20 | 0.39 |
| ▸ | GABRP | O00591 | 7/20 | 0.38 |
| ▸ | GABRD | O14764 | 7/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783671 | 0.79 | HPGD (0.58) | KDRSRCL3MBTL1HPGDMEN1 | |
| SCHEMBL10389978 | 0.77 | GABRP (0.58) | KDRSRCL3MBTL1HPGDMEN1 | |
| SCHEMBL10370302 | 0.75 | MEN1 (0.47) | KDRSRCL3MBTL1HPGDMEN1 | |
| SCHEMBL6967743 | 0.75 | GABRP (0.48) | KDRSRCL3MBTL1HPGDMEN1 | |
| SCHEMBL7581732 | 0.75 | HPGD (0.48) | KDRSRCL3MBTL1HPGDMEN1 | |
| SCHEMBL6922953 | 0.74 | GABRA2 (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10540919 | 0.73 | GABRP (0.45) | KDRL3MBTL1HPGDMEN1KMT2A | |
| SCHEMBL6926818 | 0.71 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6208048 | 0.70 | KDR (0.57) | KDRSRCL3MBTL1HPGDMEN1 | |
| SCHEMBL6208684 | 0.70 | SRC (0.57) | KDRSRCL3MBTL1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0674642-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |