Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 7/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949187 | 0.90 | NPY1R (0.79) | NPY1RALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7958736 | 0.90 | NPY1R (0.71) | NPY1RALDH1A1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL8802019 | 0.88 | NPY1R (0.71) | NPY1RALDH1A1SMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL7956724 | 0.87 | NPY1R (0.75) | NPY1RKMT2A | |
| SCHEMBL7956905 | 0.87 | NPY1R (0.83) | NPY1RALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL7959104 | 0.86 | NPY1R (0.73) | NPY1RSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL7963164 | 0.86 | NPY1R (1.00) | NPY1RSMN1; SMN2KMT2A | |
| SCHEMBL7958925 | 0.85 | NPY1R (0.71) | NPY1RKMT2AKDM4EL3MBTL1 | |
| SCHEMBL7959050 | 0.84 | NPY1R (0.87) | NPY1RSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL7957137 | 0.83 | NPY1R (0.69) | NPY1RALDH1A1KMT2AKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| EP-0789688-A4 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0789688-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997009308-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |