Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 16/20 | 0.86 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | RGS12 | O14924 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963016 | 0.93 | PLA2G2A (1.00) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8291566 | 0.92 | PLA2G2A (0.81) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL7965081 | 0.92 | PLA2G2A (0.86) | PLA2G2APLA2G1B | |
| SCHEMBL7965802 | 0.90 | PLA2G2A (0.70) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL9139483 | 0.90 | LMNA (0.76) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8297412 | 0.89 | PLA2G2A (0.87) | PLA2G2APLA2G1B | |
| SCHEMBL14446495 | 0.89 | LMNA (0.89) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL1322507 | 0.86 | LMNA (1.00) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL1320560 | 0.85 | LMNA (1.00) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8607505 | 0.85 | PTGS2 (1.00) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |