SCHEMBL7963271

SCHEMBL7963271

CC(=O)c1c(C)c(-c2cccnc2)n2c1C=CCC2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TSHR P16473 2/20 0.37
MAPK1 P28482 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CYP11B2 P19099 8/20 0.37
CYP11B1 P15538 1/20 0.37
TBXAS1 P24557 2/20 0.35
MKNK1 Q9BUB5 2/20 0.34
MKNK2 Q9HBH9 2/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
HSD17B10 Q99714 1/20 0.34
PARP10 Q53GL7 1/20 0.34
PARP11 Q9NR21 1/20 0.34
APP P05067 1/20 0.34
GPR35 Q9HC97 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8328659 0.91 GPR35 (0.38) CYP2A6CYP3A4CYP2C9CYP2C19TSHR
SCHEMBL7965530 0.90 MKNK1 (0.40) CYP2A6CYP3A4CYP2C19CYP11B2TBXAS1
SCHEMBL7963752 0.88 SLC2A1 (0.39) CYP3A4TSHRMAPK1CYP11B2CYP11B1
SCHEMBL7963276 0.87 CYP11B2 (0.39) CYP2A6CYP3A4CYP2C9CYP2C19TSHR
SCHEMBL7961877 0.85 CYP11B2 (0.40) CYP2A6CYP3A4CYP2C9CYP2C19MAPK1
SCHEMBL7962951 0.85 CYP11B2 (0.37) CYP2A6CYP3A4CYP2C9CYP2C19CYP11B2
SCHEMBL7967982 0.84 CYP11B2 (0.37) CYP2A6CYP3A4CYP2C9CYP2C19CYP11B2
SCHEMBL8328721 0.79 MKNK1 (0.38) CYP2A6CYP2C9CYP11B2MKNK1MKNK2
SCHEMBL8327786 0.79 CYP11B2 (0.37) CYP3A4CYP11B2CYP11B1MKNK1MKNK2
SCHEMBL7961492 0.79 CYP11B2 (0.43) TSHRMAPK1CYP11B2CYP11B1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207675-B1 FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA RHONE-POULENC RORER S.A. (FR) 2001-03-27 US claimed
EP-0946555-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Aventis Pharma S.A. (FR) 1999-10-06 EP claimed
WO-1998025925-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1998-06-18 WO claimed
US-6207675-B1 FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA RHONE-POULENC RORER S.A. (FR) 2001-03-27 US disclosed
EP-0946555-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Aventis Pharma S.A. (FR) 1999-10-06 EP disclosed
WO-1998025925-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1998-06-18 WO disclosed