Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422462 | 0.94 | KDM4E (0.51) | NPC1RAB9ATDP1KMT2AKDM4E | |
| SCHEMBL7426377 | 0.82 | PIK3CA (0.37) | NPC1RAB9ATDP1KMT2AKDM4E | |
| SCHEMBL7422787 | 0.81 | NPC1 (0.48) | NPC1RAB9ATDP1KMT2AKDM4E | |
| SCHEMBL7488123 | 0.81 | PDE5A (0.48) | NPC1RAB9ATDP1KMT2AKDM4E | |
| SCHEMBL7427546 | 0.75 | TUBB4A (0.42) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7420616 | 0.75 | SIRT1 (0.55) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7969332 | 0.74 | PIK3CA (0.37) | RAB9ATDP1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7971993 | 0.74 | TUBB4A (0.36) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7593178 | 0.73 | TUBB4A (0.35) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL7430971 | 0.73 | ALDH1A1 (0.68) | NPC1KMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |