Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145710 | 0.78 | DRD2 (0.40) | MAPK1CYP11B2CYP11B1DRD2SLC6A4 | |
| SCHEMBL13728399 | 0.78 | CYP11B2 (0.42) | CYP11B2CYP11B1DRD2SLC6A4KMT2A | |
| SCHEMBL8145712 | 0.77 | DRD2 (0.48) | CYP11B2CYP11B1DRD2SLC6A4HRH3 | |
| SCHEMBL7965544 | 0.77 | CYP11B2 (0.55) | CYP11B2MEN1KMT2APOLB | |
| SCHEMBL28442398 | 0.75 | TDP1 (0.41) | CYP11B2CYP11B1DRD2SLC6A4 | |
| Cyclohexane SCHEMBL22288135 | 0.74 | TDP1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL11665783 | 0.74 | TDP1 (0.44) | CYP11B2CYP11B1 | |
| Oxalic Acid SCHEMBL7963303 | 0.73 | HTR6 (0.44) | — | |
| SCHEMBL9674756 | 0.73 | DRD2 (0.50) | MAPK1DRD2SLC6A4HRH3MEN1 | |
| SCHEMBL30735834 | 0.71 | HTR2C (0.49) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |