Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 2/20 | 0.46 |
| ▸ | TK2 | O00142 | 7/20 | 0.46 |
| ▸ | TK1 | P04183 | 3/20 | 0.46 |
| ▸ | TYMP | P19971 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199538 | 0.81 | SMN1; SMN2 (0.38) | TK2TK1TYMP | |
| SCHEMBL2153725 | 0.79 | TK2 (0.39) | TK2TK1TYMP | |
| SCHEMBL6468189 | 0.78 | TK1 (0.37) | CAMK2DTK2TK1TDP1 | |
| SCHEMBL8541240 | 0.78 | TK1 (0.46) | TK2TK1TYMP | |
| SCHEMBL24420484 | 0.77 | TK2 (0.52) | TK2TK1TYMPKMT2AMAPT | |
| SCHEMBL7535820 | 0.76 | MAOA (0.39) | TK2TK1TDP1 | |
| SCHEMBL5158820 | 0.76 | TK1 (0.37) | TK2TK1 | |
| SCHEMBL8642052 | 0.76 | TK1 (0.39) | TK2TK1KMT2A | |
| SCHEMBL15110503 | 0.76 | TK2 (0.60) | TK2TK1TYMPKMT2AMAPT | |
| SCHEMBL7197137 | 0.75 | MEN1 (0.46) | TDP1KMT2AMAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232318-B1 | COMPOUNDS SUCH AS 1-BENZYL-3-(3-(4-(4-FLUOROPHENYL)PIPERIDIN -1-YL)PROPYL)-5-METHYL-1H-PYRIMIDINE-2,4-DIONE; PROVIDES RELIEF TO MALES SUFFERING FROM BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., LTD. | 2001-05-15 | — | — | US | disclosed |
| WO-2000029386-A1 | PYRIMIDINEDIONE DERIVATIVES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-25 | — | — | WO | disclosed |