Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | IL15 | P40933 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6115844 | 0.86 | CMA1 (0.63) | CMA1SMN1; SMN2POLBALDH1A1HTT | |
| SCHEMBL7965389 | 0.84 | CMA1 (0.45) | CMA1ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL7960611 | 0.73 | HRH1 (0.66) | ADRA1AHRH1ADRA1BHRH3ALDH1A1 | |
| SCHEMBL23966567 | 0.73 | MAPT (0.68) | POLBTSHR | |
| SCHEMBL23966572 | 0.71 | RECQL (0.57) | SMN1; SMN2POLBALDH1A1HTTTSHR | |
| SCHEMBL16363659 | 0.68 | TSHR (0.64) | ADRA1AHRH1ADRA1BHRH3POLB | |
| SCHEMBL7967791 | 0.68 | CMA1 (0.56) | CMA1HPGDSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL6115259 | 0.65 | CMA1 (1.00) | CMA1TSHRCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7959067 | 0.64 | CMA1 (0.85) | CMA1TSHRCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6115916 | 0.64 | CMA1 (0.81) | CMA1HPGDSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323991-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |
| WO-2010019417-A2 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | WO | disclosed |