Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.61 |
| ▸ | HRH1 | P35367 | 4/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877772 | 0.85 | TSHR (0.71) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| Talastine SCHEMBL30502 | 0.82 | ADRA1A (0.81) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| Talastine SCHEMBL29350005 | 0.82 | ADRA1A (0.81) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| Talastine SCHEMBL1650995 | 0.80 | ADRA1A (0.78) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL8556390 | 0.79 | ENPP1 (0.65) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL12862542 | 0.79 | TSHR (0.66) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL12892041 | 0.78 | TSHR (0.78) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15478270 | 0.78 | TSHR (0.82) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL13890824 | 0.76 | HRH1 (0.72) | TSHRADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL16363658 | 0.76 | HRH1 (0.68) | TSHRADRA1AHRH1ADRA1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093976-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2018-04-05 | — | — | US | disclosed |
| US-9783529-B2 | Pyridazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2017-10-10 | — | — | US | disclosed |
| US-20150005300-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB (US) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005300-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SLC26A4, PNPO | TSHR 3184/4885ADRA1A 1503/4885HRH1 798/4885 |
| US-20180093976-A1 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SLC26A4, PNPO | TSHR 3184/4885ADRA1A 1503/4885HRH1 798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.