Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | DUT | P33316 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975345 | 0.86 | CA12 (0.34) | KDM4ETP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4295990 | 0.86 | KDM4E (0.46) | KDM4EMAPK1DUTALDH1A1LMNA | |
| SCHEMBL7994068 | 0.82 | KDM4E (0.33) | KDM4EMAPK1DUTL3MBTL1NPSR1 | |
| SCHEMBL16954536 | 0.78 | KDM4E (0.43) | KDM4EMAPK1TP53CYP1A2CYP3A4 | |
| SCHEMBL12634752 | 0.78 | MAPT (0.40) | KDM4EMAPK1DUTALDH1A1LMNA | |
| SCHEMBL14804182 | 0.77 | L3MBTL1 (0.51) | MAPK1CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL29628726 | 0.77 | MAPT (0.37) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL20294518 | 0.76 | KDM4E (0.41) | KDM4EMAPK1TDP1DUTALDH1A1 | |
| SCHEMBL16959265 | 0.76 | NPC1 (0.42) | KDM4EMAPK1TP53CYP1A2CYP3A4 | |
| SCHEMBL13117518 | 0.76 | CD274 (0.40) | KDM4EMAPK1DUTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |