Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963846 | 0.92 | PARP1 (0.40) | PARP1SIGMAR1PPARGPPARATMEM97 | |
| SCHEMBL7957068 | 0.87 | PARP1 (0.44) | PARP1SIGMAR1TMEM97 | |
| SCHEMBL7960204 | 0.85 | SIGMAR1 (0.52) | PARP1SIGMAR1HTR1AHTR7 | |
| SCHEMBL7960353 | 0.85 | PARP1 (0.37) | PARP1SIGMAR1PPARGPPARAHTR1A | |
| SCHEMBL8571047 | 0.84 | HTR6 (0.39) | PARP1SIGMAR1HTR1AHTR7 | |
| SCHEMBL7963856 | 0.84 | SIGMAR1 (0.53) | PARP1SIGMAR1HTR1AHTR7 | |
| SCHEMBL7960022 | 0.83 | PARP1 (0.39) | PARP1SIGMAR1HTR1AHTR7 | |
| SCHEMBL7959426 | 0.83 | PARP1 (0.46) | PARP1SIGMAR1PPARGPPARAHTR7 | |
| SCHEMBL7959657 | 0.82 | SIGMAR1 (0.51) | PARP1SIGMAR1HTR7 | |
| SCHEMBL7949114 | 0.81 | SIGMAR1 (0.42) | PARP1SIGMAR1HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |