Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963965 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL6588339 | 0.85 | CHRM5 (0.42) | PDE4APDE4BPDE4CPDE4DHIF1A | |
| SCHEMBL6583426 | 0.84 | PDE4B (0.51) | PDE4BPDE4D | |
| SCHEMBL6582719 | 0.83 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6584261 | 0.83 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6582911 | 0.83 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6583040 | 0.82 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583108 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6581756 | 0.80 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583751 | 0.79 | SIGMAR1 (0.51) | PDE4APDE4BPDE4CPDE4DHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |