Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582719 | 0.99 | PDE4B (0.48) | PDE4BPDE4DPDE4ACHRNB4CHRNA3 | |
| SCHEMBL6583426 | 0.96 | PDE4B (0.51) | PDE4BPDE4D | |
| SCHEMBL7963965 | 0.86 | PDE4A (0.50) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6582911 | 0.83 | PDE4B (0.51) | PDE4BPDE4DPDE4AKMT2APDE4C | |
| SCHEMBL6584261 | 0.83 | PDE4B (0.51) | PDE4BPDE4DPDE4AMEN1KMT2A | |
| SCHEMBL6583752 | 0.83 | PDE4A (0.58) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6583108 | 0.82 | PDE4A (0.42) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6583656 | 0.82 | PDE4A (0.38) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6583751 | 0.80 | SIGMAR1 (0.51) | PDE4BPDE4DPDE4AMEN1KMT2A | |
| SCHEMBL7913421 | 0.80 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |