SCHEMBL6583426

SCHEMBL6583426

COc1ccc(C2CCN(C)C(=O)O2)cc1OCC1CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 19/20 0.51
PDE4D Q08499 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582719 0.97 PDE4B (0.48) PDE4BPDE4D
SCHEMBL6583040 0.96 PDE4B (0.48) PDE4BPDE4D
SCHEMBL7963965 0.88 PDE4A (0.50) PDE4BPDE4D
SCHEMBL6582911 0.85 PDE4B (0.51) PDE4BPDE4D
SCHEMBL6584261 0.85 PDE4B (0.51) PDE4BPDE4D
SCHEMBL6583108 0.84 PDE4A (0.42) PDE4BPDE4D
SCHEMBL6583656 0.84 PDE4A (0.38) PDE4BPDE4D
SCHEMBL6583751 0.82 SIGMAR1 (0.51) PDE4BPDE4D
SCHEMBL6584431 0.81 HIF1A (0.47)
SCHEMBL6583752 0.81 PDE4A (0.58) PDE4BPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0928789-B1 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME NIKKEN CHEMICALS CO LTD (JP) 2004-09-29 EP disclosed
US-6251897-B1 TREATING DERMATITIS, ASTHMA NIKKEN CHEMICALS CO., LTD (JP) 2001-06-26 US disclosed
EP-0928789-A1 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Nikken Chemicals Company, Limited (JP) 1999-07-14 EP disclosed