Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | FPR1 | P21462 | 1/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 5/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977583 | 0.91 | SMN1; SMN2 (0.50) | LMNAPRMT5WDR77POLBFPR2 | |
| SCHEMBL7974397 | 0.89 | SMN1; SMN2 (0.50) | LMNAPOLBKMT2AMAPTGAA | |
| SCHEMBL7980362 | 0.88 | SMN1; SMN2 (0.48) | LMNAPRMT5WDR77POLBFPR2 | |
| SCHEMBL7974305 | 0.86 | MAPT (0.53) | LMNAPOLBMEN1HPGDKMT2A | |
| SCHEMBL7977629 | 0.85 | SMN1; SMN2 (0.48) | LMNAPRMT5WDR77POLBMEN1 | |
| SCHEMBL7977585 | 0.84 | POLB (0.48) | LMNAPRMT5WDR77POLBMEN1 | |
| SCHEMBL7975451 | 0.83 | SMN1; SMN2 (0.56) | LMNAPRMT5WDR77POLBFPR2 | |
| SCHEMBL7964021 | 0.83 | LMNA (0.47) | LMNAPOLBMEN1KMT2AMAPT | |
| SCHEMBL7974465 | 0.83 | LMNA (0.47) | LMNAPOLBMEN1HPGDKMT2A | |
| SCHEMBL7975380 | 0.83 | LMNA (0.47) | LMNAPOLBMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |