Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.65 |
| ▸ | DRD2 | P14416 | 6/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954803 | 1.00 | HTR1A (0.65) | HTR1ADRD2DRD3 | |
| SCHEMBL7954799 | 1.00 | HTR1A (0.65) | HTR1ADRD2DRD3 | |
| SCHEMBL7954800 | 1.00 | HTR1A (0.65) | HTR1ADRD2DRD3 | |
| SCHEMBL9119950 | 0.93 | HTR1A (0.75) | HTR1ADRD2DRD3 | |
| SCHEMBL9119963 | 0.93 | HTR1A (0.75) | HTR1ADRD2DRD3 | |
| SCHEMBL7970281 | 0.89 | HTR1A (0.56) | HTR1ADRD2DRD3 | |
| SCHEMBL7955122 | 0.89 | HTR1A (0.56) | HTR1ADRD2DRD3 | |
| SCHEMBL7970277 | 0.89 | HTR1A (0.56) | HTR1ADRD2DRD3 | |
| SCHEMBL7955124 | 0.89 | HTR1A (0.56) | HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL10598576 | 0.88 | SIGMAR1 (0.64) | HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262064-B1 | AN ACTAHYDROBENZO(F)QUINOLINE-BASED COMPOUND | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION | 2001-07-17 | — | — | US | disclosed |
| US-5863928-A | TREATMENT OF PSYCHOTIC DISORDERS, PARKINSON'S DISEASE; SEDATIVES | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATION. (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0729458-A1 | OCTAHYDROBENZO[f]QUINOLINE-BASED RECEPTOR AGONISTS AND ANTAGONISTS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014006-A1 | OCTAHYDROBENZO[f]QUINOLINE-BASED RECEPTOR AGONISTS AND ANTAGONISTS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1995-05-26 | — | — | WO | disclosed |