Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | EED | O75530 | 1/20 | 0.50 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.50 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.50 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.50 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8517716 | 0.90 | GPR119 (0.45) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL1405370 | 0.85 | GPR119 (0.59) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL22558670 | 0.85 | GPR119 (0.59) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL5705691 | 0.82 | MAPT (0.52) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL4248552 | 0.82 | ALDH1A1 (0.61) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL4240647 | 0.81 | ALDH1A1 (0.52) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL4393991 | 0.81 | MMP13 (0.55) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL2520399 | 0.81 | ALDH1A1 (0.55) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL4244525 | 0.81 | ALDH1A1 (0.52) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL4239889 | 0.81 | ALDH1A1 (0.52) | MAPTNPC1ALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |