Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953304 | 0.87 | OPRL1 (0.38) | ABCB1TACR2OPRL1MEN1KMT2A | |
| SCHEMBL7964373 | 0.86 | ABCB1 (0.63) | ABCB1 | |
| SCHEMBL7953354 | 0.85 | ALPL (0.36) | DRD2DRD3TACR2TACR1OPRL1 | |
| SCHEMBL7964370 | 0.83 | ABCB1 (0.43) | ABCB1SRCTGFBR1PTGDR2OPRL1 | |
| SCHEMBL7962733 | 0.83 | ABCB1 (0.39) | ABCB1DRD2DRD3TACR2TACR1 | |
| SCHEMBL7967126 | 0.83 | ABCB1 (0.39) | ABCB1DRD2DRD4DRD3SRC | |
| SCHEMBL7966953 | 0.82 | OPRL1 (0.39) | TACR2OPRL1MEN1KMT2A | |
| SCHEMBL7953964 | 0.81 | HTR1A (0.40) | ABCB1DRD2DRD3TACR2TACR1 | |
| SCHEMBL7969555 | 0.80 | OPRL1 (0.45) | TACR2OPRL1MEN1KMT2A | |
| SCHEMBL7966030 | 0.80 | ABCB1 (0.38) | ABCB1DRD2TACR2OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |