Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 13/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953292 | 0.87 | MAPT (0.41) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL8019949 | 0.85 | L3MBTL1 (0.37) | OPRM1OPRD1OPRK1OPRL1ITGA4 | |
| SCHEMBL7964373 | 0.85 | ABCB1 (0.63) | ABCB1 | |
| SCHEMBL7964376 | 0.83 | ABCB1 (0.44) | ABCB1PTGDR2SRCTGFBR1OPRL1 | |
| SCHEMBL7967120 | 0.83 | ABCB1 (0.41) | ABCB1PTGDR2SRCTGFBR1ITGA4 | |
| SCHEMBL7962723 | 0.83 | MAP4K4 (0.36) | ABCB1ITGA4ITGB7 | |
| SCHEMBL7966948 | 0.82 | OPRM1 (0.39) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7953961 | 0.80 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1ITGA4 | |
| SCHEMBL7969551 | 0.80 | MEN1 (0.41) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7966027 | 0.80 | MAPT (0.37) | ABCB1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |