SCHEMBL7964667

SCHEMBL7964667

c1ccc(COc2ccnc(-c3cc(OCc4ccccc4)ccn3)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.56
CYP3A4 P08684 1/20 0.54
MAOB P27338 7/20 0.53
NR4A2 P43354 1/20 0.53
CYP4F2 P78329 1/20 0.50
CYP4A11 Q02928 1/20 0.50
BCHE P06276 1/20 0.50
LMNA P02545 1/20 0.50
CYP1A2 P05177 1/20 0.50
PTGS1 P23219 1/20 0.50
SLC6A2 P23975 1/20 0.50
CYP2C19 P33261 1/20 0.50
PTGS2 P35354 1/20 0.50
SLC6A3 Q01959 1/20 0.50
HIF1A Q16665 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
MAOA P21397 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
NSD2 O96028 1/20 0.49
ABL1 P00519 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7967199 0.93 CYP3A4 (0.53) ALOX5CYP3A4MAOBNR4A2LMNA
SCHEMBL14745014 0.83 GABRA5 (0.61) ALOX5CYP3A4MAOBNR4A2CYP4F2
SCHEMBL16025388 0.83 ALOX5 (0.55) ALOX5CYP3A4MAOBNR4A2CYP4F2
SCHEMBL15779670 0.81 MAOB (0.59) ALOX5CYP3A4MAOBNR4A2CYP4F2
SCHEMBL351009 0.81 CYP1A2 (0.56) ALOX5CYP3A4MAOBNR4A2CYP4F2
SCHEMBL29769046 0.81 CYP1A2 (0.56) ALOX5CYP3A4MAOBNR4A2CYP4F2
SCHEMBL190912 0.81 MAOB (0.59) ALOX5CYP3A4MAOBCYP4F2CYP4A11
SCHEMBL190551 0.81 ALOX5 (0.53) ALOX5CYP3A4MAOBNR4A2CYP4F2
SCHEMBL1563949 0.81 MAOB (0.54) ALOX5CYP3A4MAOBCYP4F2CYP4A11
SCHEMBL29651991 0.81 MAOB (0.59) ALOX5CYP3A4MAOBCYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187928-B1 TREATING FUNGAL DISEASES THE ROCKEFELLER UNIVERSITY 2001-02-13 US disclosed
US-6087510-A Method of use of imidazolium cations THE ROCKEFELLER UNIVERSITY (US) 2000-07-11 US disclosed
US-5969150-A FLUORESCENT COMPOUNDS FOR MEDICAL DIAGNOSIS, DRUGS AND LABELS OR FUNGICIDES AND VIRICIDES THE ROCKEFELLER UNIVERSITY (US) 1999-10-19 US disclosed
US-5874587-A FLUORESCENCE THE ROCKEFELLER UNIVERSITY (US) 1999-02-23 US disclosed