SCHEMBL7967199

SCHEMBL7967199

c1ccc(COc2ccnc(-c3ccccn3)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.53
ALOX5 P09917 1/20 0.50
ALDH1A1 P00352 2/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
KDM4E B2RXH2 3/20 0.48
LMNA P02545 2/20 0.48
HPGD P15428 1/20 0.48
TSHR P16473 1/20 0.48
ALOX12 P18054 1/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
NR4A2 P43354 1/20 0.47
MAOB P27338 4/20 0.47
CYP1A2 P05177 1/20 0.47
POLB P06746 1/20 0.47
CCR1 P32246 1/20 0.47
CCR5 P51681 1/20 0.47
CCR8 P51685 1/20 0.47
METAP1 P53582 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7964667 0.93 ALOX5 (0.56) CYP3A4ALOX5LMNASMN1; SMN2NR4A2
SCHEMBL14745014 0.81 GABRA5 (0.61) CYP3A4ALOX5LMNASMN1; SMN2NR4A2
SCHEMBL20653207 0.80 P4HTM (0.54) CYP3A4KDM4ELMNASMN1; SMN2MAOB
SCHEMBL2873418 0.80 CYP3A4 (0.52) CYP3A4ALOX5ALDH1A1MEN1KMT2A
SCHEMBL9679303 0.79 CCR1 (0.50) CYP3A4ALOX5ALDH1A1MEN1KMT2A
SCHEMBL23406054 0.78 HPGDS (0.52) CYP3A4ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL29743942 0.78 HPGDS (0.52) CYP3A4ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL27743534 0.78 CYP1A2 (0.61) CYP3A4MEN1KMT2ALMNASMN1; SMN2
SCHEMBL16025388 0.77 ALOX5 (0.55) CYP3A4ALOX5LMNASMN1; SMN2NR4A2
SCHEMBL501711 0.77 MAOB (0.60) CYP3A4ALOX5MEN1KMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187928-B1 TREATING FUNGAL DISEASES THE ROCKEFELLER UNIVERSITY 2001-02-13 US disclosed
US-6087510-A Method of use of imidazolium cations THE ROCKEFELLER UNIVERSITY (US) 2000-07-11 US disclosed
US-5969150-A FLUORESCENT COMPOUNDS FOR MEDICAL DIAGNOSIS, DRUGS AND LABELS OR FUNGICIDES AND VIRICIDES THE ROCKEFELLER UNIVERSITY (US) 1999-10-19 US disclosed
US-5874587-A FLUORESCENCE THE ROCKEFELLER UNIVERSITY (US) 1999-02-23 US disclosed