Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122423 | 0.83 | CRHR1 (0.55) | CRHR1CDK4CCND1TDP1KDM4E | |
| SCHEMBL7965430 | 0.83 | CDK4 (0.62) | CRHR1CDK4CCND1 | |
| SCHEMBL7964689 | 0.79 | CDK4 (0.56) | CRHR1CDK4CCND1HPGD | |
| SCHEMBL7937098 | 0.74 | CRHR1 (0.46) | CRHR1CDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL7928892 | 0.73 | KDM4E (0.49) | CRHR1CDK4CCND1TDP1KDM4E | |
| SCHEMBL7360292 | 0.73 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL5599759 | 0.72 | CRHR1 (0.87) | CRHR1TDP1 | |
| Hydrochloric Acid SCHEMBL7953091 | 0.72 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL7354421 | 0.72 | CRHR1 (0.54) | CRHR1 | |
| Hydrochloric Acid SCHEMBL8127656 | 0.72 | CRHR1 (0.69) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |