Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 11/20 | 0.49 |
| ▸ | HTR1A | P08908 | 9/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766219 | 0.87 | MAPK14 (0.43) | ADRA1BHTR1AADRA1DADRA1AMAPK14 | |
| SCHEMBL2215555 | 0.87 | MAPK14 (0.43) | ADRA1BHTR1AADRA1DADRA1AMAPK14 | |
| SCHEMBL12012111 | 0.85 | NFE2L2 (0.47) | ADRA1BHTR1AADRA1DTAAR1TDP1 | |
| SCHEMBL22710272 | 0.84 | TDP1 (0.59) | ADRA1BHTR1AADRA1DADRA1ATDP1 | |
| SCHEMBL12047605 | 0.82 | ADRA1B (0.41) | ADRA1BHTR1AADRA1DADRA1ATAAR1 | |
| SCHEMBL1133835 | 0.82 | ALDH1A1 (0.43) | ADRA1BHTR1AADRA1DADRA1AMAPK14 | |
| SCHEMBL1133834 | 0.82 | ALDH1A1 (0.43) | ADRA1BHTR1AADRA1DADRA1AMAPK14 | |
| SCHEMBL10762275 | 0.82 | PLA2G4B (0.43) | ADRA1BHTR1AADRA1DADRA1ATMEM97 | |
| SCHEMBL10762271 | 0.82 | PLA2G4B (0.43) | ADRA1BHTR1AADRA1DADRA1ATMEM97 | |
| SCHEMBL10760498 | 0.81 | MAPK14 (0.40) | ADRA1BHTR1AADRA1DADRA1ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |