Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.38 |
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252152 | 0.91 | TGFBR1 (0.41) | TGFBR1ROCK2CDK2CDK4CCNE1 | |
| SCHEMBL10252401 | 0.89 | ROCK2 (0.42) | TGFBR1ROCK2CDK2CCNE1KDM4E | |
| SCHEMBL700609 | 0.80 | CDK2 (0.47) | CDK2CDK4MAPK10CCNE1KDM4E | |
| SCHEMBL7980583 | 0.79 | CDK2 (0.50) | TGFBR1CDK2CDK4CCNE1KDM4E | |
| SCHEMBL7975428 | 0.79 | CDK2 (0.47) | CDK2CDK4CCNE1KDM4EMAPT | |
| SCHEMBL7978508 | 0.79 | CDK2 (0.51) | CDK2CDK4MAPK10CCNE1KDM4E | |
| SCHEMBL10252165 | 0.78 | CDK2 (0.49) | TGFBR1CDK2CDK4CCNE1KDM4E | |
| SCHEMBL7978153 | 0.78 | HDAC1 (0.51) | CDK2CDK4CCNE1HDAC1MAPK14 | |
| SCHEMBL10252007 | 0.77 | IGF1R (0.45) | ROCK2CDK2CDK4CCNE1MAPK14 | |
| SCHEMBL700463 | 0.77 | HDAC1 (0.60) | CDK2CDK4CCNE1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |