Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328495 | 0.91 | CTSK (0.50) | HDAC3POLBSIGMAR1CTSKCA12 | |
| SCHEMBL4583683 | 0.85 | POLB (0.65) | POLBSIGMAR1CTSKCYP2D6CYP2C9 | |
| SCHEMBL27526855 | 0.85 | L3MBTL1 (0.53) | HDAC3CA12CA1CA7CA14 | |
| SCHEMBL4092052 | 0.83 | L3MBTL1 (0.55) | CA12CA1CA7CA14L3MBTL1 | |
| SCHEMBL4632779 | 0.81 | CA12 (0.60) | CTSKCA12CA1CA7CA14 | |
| SCHEMBL4961185 | 0.81 | SIGMAR1 (0.62) | POLBSIGMAR1KMT2AIDO1MMP8 | |
| SCHEMBL4092031 | 0.80 | CA12 (0.46) | HDAC3POLBCA12CA1CA7 | |
| SCHEMBL12333754 | 0.80 | SIGMAR1 (0.58) | POLBSIGMAR1CTSKCA1CYP2D6 | |
| SCHEMBL12329858 | 0.80 | SIGMAR1 (0.57) | POLBSIGMAR1CTSKCYP2D6CYP2C9 | |
| SCHEMBL10724610 | 0.80 | MAPT (0.58) | POLBSIGMAR1KMT2AL3MBTL1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214826-B1 | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 2001-04-10 | — | — | US | disclosed |