Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475885 | 0.85 | CHRM2 (0.37) | ADORA2AADORA3NR1H2 | |
| SCHEMBL7967420 | 0.85 | BRD4 (0.46) | BRD4PIM1PIM2ADORA2AADORA1 | |
| SCHEMBL7593155 | 0.83 | AAK1 (0.38) | ADORA2AADORA3NR1H2 | |
| SCHEMBL7484398 | 0.81 | CKS1B (0.42) | BRD4PIM1PIM2NR1H2 | |
| SCHEMBL7972272 | 0.77 | BRD4 (0.43) | BRD4ADORA2AADORA1STK17BSTK17A | |
| SCHEMBL7484481 | 0.77 | DCTPP1 (0.47) | NR1H2 | |
| SCHEMBL8290003 | 0.75 | LMNA (0.64) | BRD4STK17BSTK17A | |
| SCHEMBL30849526 | 0.74 | ALDH1A1 (0.61) | BRD4PIM1PIM2STK17BSTK17A | |
| SCHEMBL25342079 | 0.73 | CA1 (0.42) | BRD4STK17BSTK17A | |
| SCHEMBL8041119 | 0.71 | STK17B (0.46) | BRD4ADORA2AADORA1STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |