Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31703587 | 0.80 | RAB9A (0.61) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 | |
| SCHEMBL31458446 | 0.80 | ALDH1A1 (0.50) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 | |
| SCHEMBL7966522 | 0.78 | CYP3A4 (0.44) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 | |
| SCHEMBL7970193 | 0.77 | ALDH1A1 (0.48) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 | |
| SCHEMBL7955026 | 0.75 | MEN1 (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL19411398 | 0.75 | BACE1 (0.43) | CYP1A2SLC6A4CYP2C19RAB9A | |
| SCHEMBL7968273 | 0.75 | KMT2A (0.57) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 | |
| SCHEMBL7970187 | 0.74 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CYP1A2RAB9AMAPT | |
| SCHEMBL29733200 | 0.72 | MEN1 (0.57) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 | |
| SCHEMBL21000902 | 0.72 | MEN1 (0.57) | ALDH1A1CYP3A4HTR3EHTR3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |